summary

Gut contains a full microbiome of bacteria, their products move to the blood and some through the brain barrier.

Health and brain function are tied to:

• Diverse microbiome
• Reduced state of inflammation

Inflammation of the intestinal barrier reduces the capacity of the gut to filter out bad molecules (leaky gut), which in terms alter the functioning of the brain. It is directly caused by the composition of the flora, and some other factors. Sugar and omega 6 causes inflammation, omega 3 and fibers reduce it.

Composition of the flora can be altered through food. Therefore following a diet that is low on transformed sugar and carbs, and high in proteins and omega 3 can help reduce neurologicaly driven issues.

Therefore:

1. Low carbs, low sugar, low / no gluten.
2. High fiber, omega 3.
3. Some protein.
4. Fermented food.
5. Fast once in a while.

notes

Gut biome linked to health, including cerebral. Lots of neurons in the gut.

Biome in the body represents 4-5kg, and 300x the genome of a person.

Autism, asthma, anxiety, allergies, depression, dementia, weight management, ... are linked to composition of the gut biome, and can be treated with that.

Serotonine is produced mainly in the gut.

Gut micro biome

• Fermicutes - good at extracting caloried from food, more present in urban settings, linked to weight gains
• Bacteroidota - less so, more present in rural places.

blood sugar

• Linked to dementia
• Linked to inflamation
• Much harder to control if your sugar input is higher

produced in the gut

• B12, ggaba, bdnf, glutamate, all contributors to health and brain functions

  inflamation

• Linked to a bunch of mental disabilities.
• Prevents intestinal barrier (aka gut lining ) to work properly
• LPS in blood is a good indicator of inflammation, going through because of too much permeability
  => the "leaky gut syndrome" (too much permeability). Side note - does not seem to be admitted as a real syndrome

  b12

Synthesized in the gut, reduces risk factor for mental diseases, and depression

Food rich in fiber and low in refined sugar supports robust blend of bacteria

inflammation

Increased gut permeability and bacterial diversity

Mediterranean diet - rich in omega 3 fats and proteins experience less depression

High carbs and sugar sets an inflammatory microbiome

Fructose increases circulating lps by 40%. Can be restored

auto immune disease and depression

Immune response linked to risk of depression. Hospitalization linked to later risks of depression. Antibiotics as well.

Lower level of bdnf linked to depression

We know that

• Probiotics help with how our brain responds with negativity
• What we eat affects the compositionand products flora. High vegetables and fibre based have a different composition of their flora than high carbs and fat diet. Also impact brain functions

Anxiety and depression are very linked. The main difference is that anxiety is characterized by apprehension, nervousness, and exaggerated fear and pessimistic view of the future, while depression doesn't entail fears and revolves around a sense of helplessness, life is bad and nothing can go right

Autism has causes linked to molecules toxic to the brain issued by the gut. Correlated with low diversity and low bifidobacteria. Also linked to clostridya and PPA, which is reduced by omega 6 NAC (N-acetylcysteine) and l-karnatine - reduce irritability and reduce repetitive behaviour in children with autism. Many other causes, but aggravated by gut. B-fragilis has also worked. All that to say, autism is very complex, healthy gut makes it better.

actual advice

1. Dont eat high fructose corn syrup, that's the worst
2. Gluten free
3. Don't eat artificial sweeteners, they're not neutral.

Follow a diet with low carbs, high fiber, some protein. Get a lot of pre-biotics (12g a day). These are present in stuff like ginseng and some roots. Use natural oils rich in Omega 3 (olive, coconut). Eat fermented food (saurkraut, kimchi, yogurt, kefir) to get probiotics.

Drink filtered water because of the chlorine. Avoid antibiotics and meat raised with antibiotics (prefer organics). Avoid food that received pesticide, and OGMs (as they are usually paired with pesticides).

Fast 4x a year for between 24 and 72h.

Do an enema, with probiotics in there.

Fecal matter transplant is the future.